Newborn Clinic

Specialization: Molecular biology, human reproduction and embryology

ESHRE certification for Clinical Embryologist, National representative for IVF from Macedonia (Committee of National representatives ESHRE)

 

Education

Postgraduate Education:

2017:     Associate Professor for Human Reproduction and Molecular Biology and Genetics, Faculty of Natural Sciences and Mathematics, University “St. Cyril & Methodius”, Skopje

2015:     PhD thesis: “DNA fragmentation in the sperm in infertile men and embryological parameters for patients’ ongoing IVF treatments”. Faculty of Natural Sciences and Mathematics, University “St. Cyril & Methodius”, Skopje

2006:    MSc. in Biology (Molecular Biology).  Faculty of Natural Sciences and Mathematics, University “St. Cyril & Methodius”, Skopje (Thesis Title: “Detection and typing of human papillomavirus with PCR-RFLP technique in cervical lesions”);

               Graduate studies at the Faculty of Natural Sciences and Mathematics, University “St. Cyril & Methodius”, Skopje (GPA 10 on 5-10 scale)

Faculty:

2001:     B.Sc. in Biology (Biochemistry and Physiology), 2001.  Faculty of Natural Sciences and Mathematics, University “St. Cyril & Methodius”, Skopje (GPA 9.22 on 5-10 scale) (Thesis Title: “PCR-based detection and typization of human papillomavirus in cervical swabs”)

 

Qualifications:

Associate Professor for Human Reproduction and Molecular Biology and Genetics

PhD – Molecular biology

Master of Science – Molecular biology, Graduated Engineer of Biology (Biochemistry-Physiology)

 

Teaching experience:

2006 – 2008   

Instructor in practical courses of the following subjects:

Molecular Biology for the Biology students (5^th and 6^th semester)

Basics of Molecular Biology for the Analytical Chemistry students(6^th semester)

Molecular Genetics for the Analytical Chemistry students (7^th semester)

Basics of Biology for Dentistry students (1^th semester)

 

Research experience:

1999 – 2007:               Part-time employment at Laboratory for Molecular Biology, Department of Biology, Faculty of Natural Sciences and Mathematics, University “St. Cyril & Methodius” in Skopje as a research assistant for HPV detection and genotyping of more than a 13 000 analysis on patients samples from the University Gynecological Clinic and from private ordinations.

 

Membership:

2018-2022:                 Member of National Committee for biomedical assisted reproduction (Ministry of health of Republic of Macedonia)

2015-2019:                  National representative for IVF from Macedonia (Committee of National representatives ESHRE)

2013:                            Member of Association of Clinical Embryologist (United Kingdom)

2012:                            Member of Macedonian society of Human reproduction

2009- present:           Member of ESHRE (European Society of Human Reproduction and Embryology)

2007- present:           Elected General Secretary of the Human PapillomaVirus Society of Macedonia

2006- present:           Society of Medical biochemists of Macedonia

2003- present:           Society of Infectologyst of Macedonia

1998-1999:                  Elected President of the Biology Students Research Society, Faculty of Natural Sciences and Mathematics, University “St. Cyril & Methodius”, Skopje

1997-1998:                  Elected Secretary of the Biology Students Research Society in 1998, Faculty of Natural Sciences and Mathematics, University “St. Cyril & Methodius”, Skopje

 

Training and courses:

2020:               Implementing Good Laboratory Practice in the time of COVID-19, CooperSurgucal

2019:               Best practice in PGD, 07-08 Dec, Thessaloniki, Greece

2018:               ESHRE 34^TH Annual Meeting, 1-4 July, 2018 Barcelona, Spain

2017:               Ovarian club: Bulding a brigde between science and clinical practice, Barcelona

2017:               The 3^rd World Congress in preconception, preimplantation and prenatal genetic diagnosis (CoGen), Barcelona

2016:               ESHRE 32^TH Annual Meeting, 3-6 July, 2016 Helsinki, Finland

2015:               Cryopreservation of gametes, embryos and ovarian tissue: Hands-on workshop organized by Embryolab Academy, Thessaloniki, Greece

2015:               BioRad Workshop: Technologies and techniques in Life Science Research, May, Skopje.

2015:               Biomedika Workshop: “Molecular diagnostic; Methods and clinical utility”, May, Skopje.   

2014:               ESHRE 29 th Annual Congress, July, Munich.

2013:               ESHRE certification for Clinical Embryologist, London, UK.

2013:               Preimplantation Genetic Diagnosis 2013 – Hands-on workshop organizedby Embryolab Academy, Thessaloniki, Greece.                     

2013:               Clinical observation program for fertility – Sofia, Bulgaria.

2012:               Workshop for LifeGlobal media: vitrification system, (Ana Lopez), Istanbul.

2012:               Workshop for Culture media: the best environment for gametes and          embryos, ESHRE, annual meeting, Istanbul, Turkey.

2011:               Education for Oocyte and Embryo Vitrification (Ana Cobo, Spain; M. Kuwayama, Japan)  – Controversies in Cryopreservation of Stem Cells, Reproductive Cells, Tissue & Organs (CRYO) – Valencia, Spain                       

2012:               Workshop for Culture media organized by ESHRE annual metting, Istanbul, Turkey.

2012:               Vitrification media and protocols (Global workshop, organized in Acibadem hospital, Istanbul at ESHRE annual metting)

2010:               The 4^th International IVI Congress, Hands-on workshop: Oocyte vitrification in a closed system by A. Cobo, Spain and A. Kuwayama, Japan.

2009 :              ESHRE Simposium – The patient friendly approach to ART , From a natural cycle to minimal stimulation and single embryo transfer , Maribor, Slovenia 2009.

2008 :              Brussel’s Women’s Health & Infertility Center, Prof. Yucel Karaman IVF laboratory,  Istanbul, Turkey.

 

Publications:

Book chapter : Milanova E, Trajkova K, Panov S, Stojanovska V. Human Papillomavirus Typisation by Polymerase Chain Reaction, Made on an Infected Tissue of the Uterine Cervix-Our Experience. In: Vliet HV, editors. Cancer Research Trends. NOVA Science Publishers, Inc. Hauppauge NY. 2007. 2nd quarter. ISBN-13:978-1-60021-648-0.

 

Scientific papers:  

1. S Stojkovska, G Dimitrov, Z Petanovski, D Shushleski, S Saltirovski, V Matevski, M Hadzi Lega, V Sotirovska, D Stojanovska, N Stamenkovska, E Petanovska Kostova, R Latifi Isaki. A novel method of treating ovarian infertility: Is platelet-rich plasma a new promising therapy in the future? MMP 2021.
2. Kostova EP, Sotirovska V, Stojanovska D, Prodanova I, Petanovski Z. Immature Ovarian Teratom Donald School J Ultrasound Obstet Gynecol 2020; 14 (4):359-363.
3. E Petanovska Kostova, V Sotiroska, G Dimitrov, S Stojkovska, M Hadzi Lega, D Stojanovska, N Stamenkovska, L Simjanovska, Z Petanovski. Different Timing of Adjuvant Low Dose hCG and GnRH Agonist Trigger Protocol, in OHSS High-Risk Patient with Peak E2 Level. Gynecol Obstet Reprod Med. 2020;26(0):000-000.
4. Anna Veiga (Sotiroska V. as participant). The ESHRE COVID-19 Working Group , Nathalie Vermeulen, Baris Ata, Luca Gianaroli, Kersti Lundin, Edgar Mocanu, Satu Rautakallio-Hokkanen, Juha S Tapanainen. A picture of medically assisted reproduction activities during the COVID-19 pandemic in Europe. Human Reproduction Open. Issue 3. 2020/8/17.
5. PID Noveski, M Vujovic, M Terzic, D Shushleski, V Sotiroska, Z Petanovski, D Plaseska-Karanfilska. Revealing hidden phenotypes in the Mendelian disorders: teratozoospermia due to KRT9 pathogenic variant? Eur J Hum Gen; Vol 27, 1819-1819, 2019.
6. The ESHRE Working Group on Oocyte Cryopreservation in Europe ShenfieldJ. de Mouzon G. Scaravelli M. Kupka A.P. Ferraretti F.J. Prados V. Goossens (Sotiroska V. as participant). Oocyte and ovarian tissue cryopreservation in European countries: statutory background, practice, storage and use. Hum reprod open. Volume 2017, Issue 1, 2017.
7. Valentina Sotiroska, Gligor Dimitrov, Zoranco Petanovski, Snezana Stojkovska, Andrijana Sterjovska-Aleksovska. Influence of embryo transfer day on pregnancy outcomes. Journal of Perinatal Medicine, 45; 2017.
8. Valentina Sotiroska, Zorancho Petanovski, Gligor Dimitrov, Makjuli Hadji-Lega, Damjan Shushleski, Stefan Saltirovski, Vladimir Matevski, Simona Shenbakar, Sasho Panov, Lars Johansson. The Day of ET affects delivery rate, birth weights, the female/male ratio and the monozygotic twin rate. Taiwan J Obstet Gynecol. 2015; Vol 54, Issue 6, 716-21.
9. Gligor Dimitrov, Valentina Sotiroska, Goran Dimitrov, Andrijana Sterjovska, Sasho Panov Human Papillomavirus Infection in Cervical Precancerous Lesions. Wulfenia. 2015: Vol 22, Issue 7.
10. Kovačič B, Plas C, Woodward BJ, Verheyen G, Prados FJ, Hreinsson J, De los Santos MJ, Magli MC, Lundin K, Plancha CE (Sotiroska V. as participant). The educational and professional status of clinical embryology and clinical embryologists in Europe. Hum Reprod. See comment in PubMed Commons below2015 Jun 12. pii: dev118.
11. Noveski P, Madjunkova S, Maleva I, Sotiroska V, Petanovski Z, Plaseska-Karanfilska D. A homozygous deletion of the DPY19L2 gene is a cause of globozoospermia in men from the Republic of Macedonia. 2013:16;73-6.
12. Petanovski Z, Dimitrov G, Aydin B, Hadzi-Lega M, Sotiroska V, Susleski D, Saltirovski S, Matevski V, Stojkovska S, Petanovska E, Savic M, Balkanov Impact of active female smoking on controlled ovarian stimulation in intracitoplasmic sperm insemination cycles. Med Glas Ljek komore. Zenicko-doboj kantona. 2012; 9[2], 273-80.
13. Petanovski Z, Dimitrov G, Aydin B, Hadzi-Lega M, Sotiroska V, Matevski V, Stojkovska S, Saltirovski S, Suslevski D, Petanovska E. Impact of body mass index (BMI) and age on the outcome of the IVF process. Prilozi. 2011;32(1):155-71.
14. Petanovski Z, Dimitrov G, Aydin B, Hadzi-Lega M, Sotiroska V, Suslevski D, Saltirovski S, Matevski V, Stojkovska S, Lazarova A, Petanovska E, Balkanov T. Recombinant FSH versus HP-HMG for controled ovarian stimulation in intracitoplasmic sperm injection cycles. Med Arh. 2011;65(3):153-6.
15. Petanovski Z, Hadzi Lega M, Stojanovska V. Patients age as a marker in successful of in vitro fertilization at normogonadotropins condition. Medicus, 2009:7, (2) 94-102.
16. Петановски З, Хаџи Лега М, Стојановска В, Салтировски С, Корелација помеѓу бројот на преантралните фоликули и успехот на ин витро фертилизајата; Мedicus, 7, (2),103-11.
17. Stojanovska V, Panov S, Basheska N, Josifovska S, Dimitrov G, Petanovski Z, Stojkovski J, Hadzi Lega M. Prevalence and distribution of human papillomavirus in clinical suspicions cervical lesions. 2009.
18. Stojanovska V, Panov S, Gligorov D, Basheska N, Dimitrov G. Age distribution of Human Papillomavirus Infection among Macedonian females with Cervical Lesions. Biologia Macedonica.
19. Dimitrov G, Panov S, Stojanovska V, Milenkova S, Basheska N. Carbon dioxide laser vaporization in treatment of the cervical intraepithelial neoplasia. Acta Chir. Maced, 3, N^O2. pp.7-17, 2004.

 

Congress presentation abstracts:

1. Petanovski, G. Dimitrov, M. Hadzi Lega, D. Shushleski, V. Matevski, S. Saltirovski, S. Stojkovska, E. Petanovska, V. Sotiroska. The Impact of Male Smoking on Intracytoplasmic Sperm Injection outcomes in In vitro fertilization procedures. Abstract book of the 34th Annual Meeting of the ESHRE, Barcelona, Spain 1 to 4 July 2018. Human reproduction vol, 33, supp 1, 2018.
2. Sotiroska V, Saltirovski S, Matevski V, Shuslevski D, Sterjovska A. Cryopreservation of oocytes-our experience. Ohrid, May 16-19, 2013.
3. Latifi Isaki R, Petanovski Z, Sotiroska V, Stojkovska S, Dimitrov Gl. Obstetric outcomes of laparoscopic cervical-isthmic cerclage: our experienc Ohrid, May 16-19, 2013.
4. Sotiroska V, Saltirovski S, Matevski V, Susleski D, Petanovski Z, Dimitrov G. Intracytoplasmatic sperm injection outcome of extracted testicular spermatozoa in azozoospermic men. 3^rd Congress of gynecologists and obstetrics of Macedonia. Abstract book. HP 12, Ohrid, May 16-19, 2013.

5. Stojkovska S, Hadzi Lega M, Shushleski D, Sotiroska V, Saltirovski S, Matevski V. Influence of deepness of embryotransfer on the IVF results. 3^rd Congress of gynecologists and obstetrics of Macedonia. Abstract book. HP 12, Ohrid, May 16-19, 2013.
6. Шушлевски Д, Салтировски С, Матевски В, Сотироска В, Петановски З, Хаџи-Лега М. Користењето на различни гонадотропини во индукцијата на овулација и ефект на истите во изборот на квалитетни ембриони за замрзнување. 3^ти Конгрес на гинеколози и акушери на Македонија. Книга на апстракти, ХП 11. Охрид, 16-19 мај, 2013.
7. Plaseska-Karanfilska D, Noveski P, Madjunkova S, Maleva I, Sotiroska V, Petanovski  A homozygous deletion of DPY19L2 gene is a cause of globozoospermia in men from the Republic of Macedonia. American Society of Human Genetics. San Francisco, November 6-10. Abstract Book, p. 235. 2012.
8. Veljanovska L, Petanovski Z, Sotiroska V, Aydin B, Suslevski D, Saltirovski S, Matevski V, Dimitrov G, Hadzi-Lega M, Stojkovska S. Estradiol level as a predictor and HCG as confirmation of the success in IVF induction cycles. 20^th Meting of Balkan clinical laboratory federation. Belgrade, Abstract book p.75. 2012.
9. Хаџи-Манчева Р, Поп-Лазарова М, Спасова Л, Живковиќ Ј, Анастасовска Ј, Сотироска В. Новородени од бремености конципирани со ин витро фертилизација во ПОБ Ремедика. 5^th Congress of Pediatric association of Macedonia with internation participation. Ohrid, October 5-9, 2011.
10. Veljanovska L, Sotiroska V, Aydin B, Suslevski D, Saltirovski S, Matevski V, Petanovski Z, Dimitrov G, Hadzi-Lega M, Stojkovska S. Serum estradiol the day of hCG administration as predictor factor of IVF according to patient age.. 19^th Meting of Balkan clinical laboratory federation. Bucharest, september 21-23, 2011
11. Petanovski, Z, Susleski D, Hadzi-Lega M, Aydin B, Sotiroska V, Radeskа B, Saltirov S, Matevski V. (2010): Komparativna studija transvaginalne rane aspiracione kiretaze folikula I klasicne aspiracije folikula u procesu in vitro fertilizacije. Mediterranean Symposium in Reproductive Medicinie, Budva, Monte Negro. May 6-8, 2010.
12. Kuzmanoski M, Dimitrov G, Hadzi-Lega M, Stojkovska S, Sotiroska V, Aidin B, Saltirovski S, Suslevski D, Matevski V, Petanovski Z. Microdissection-TESE-optimal approach for patient with non-obstructive azoospermia. EAU 7th South Eastern European Meeting in Skopje. October 14-15, 2011.
13. Stojanovska V, Panov S, Basheska N, Panova D I, Alulovski I, Babushku J, Dimitrov G. PCR-based detection of human papillomavirus in Macedonian women with cervical precursor lesions confirmed by cytology and/or histopathology. 15^th International meeting of the European society of gynecological oncology. (ESGO). Berlin, Germany. 2007.
14. Panova D I, Alulovski I, Babushku J, Dimitrov G, Stojanovska V, Panov S, Basheska N. Age-specific prevalence of HPV infection in Macedonian females with cervical lesions. 15^th International meeting of the European society of gynecological oncology (ESGO). Berlin, Germany. 2007.
15. Andonovska J, Panov S, Stojkovska S, Mihova S, Stojanovska V, Vidinic I. Human Papillomavirus and RNA interference.A model of in vitro gene therapy for virus induced diseases. Congress of infectious diseases. Ohrid. 2007.
16. Stojanovska V, Panov S, Basheska N, Stojovski M. Human Papillomavirus infection in Macedonian patients with cervical lesions. 14^th Meeting of the Balkan Clinical Laboratory Federation. 27-30 september, Sofia, Bulgaria. 2006.
17. Stojanovska V., Panov S., Stojovski M., Babushku J., Dimitrov G., Ivanova-Panova D., Jovcevski S. Prevalence of Human Papillomavirus at patients with cervical lesions on the Clinic for Gynecology and Obstetrics in Skopje. First Ohrid Meeting of Gynecologists and Perinatologists, Ohrid, Abstract Book, pp. 174-175, 2005.
18. Stojovski M., Milanova E., Tanturovski D., Nikolovska E., Stojkovska S., Stojanovska V. Prevalence of oncogenic Human Papillomaviruses at high risk lesions of the uterine cervix. First Ohrid meeting of Gynecologists and Perinatologists, Ohrid, Abstract Book, p.169, 2005.
19. Milanova E., Stojovski M., Tanturovski D., Trajkova K., Businoska G., Pavlovski B., Panov S., Stojanovska V. Comparison of the prevalence of Human Papillomavirus types in high- and low-grade precancerous lesions of the uterine cervix. First Ohrid Meeting of Gynecologists and Perinatologists, Ohrid, Abstract Book, pp. 166-167, 2005.
20. Ivanova-Panova D., Babusku J., Jovcevski S., Stojanovska V., Panov S., Hadji Niceva B., Grncarovska Z. Analysis of the results of PAP smears in patients with unsuccessful HPV DNA PCR typing. First Ohrid Meeting of Gynecologists and Perinatologists, Ohrid, Abstract Book, pp. 145-146, 2005.
21. Stojanovska V., Panov S., Gligorov D., Stojovski M., Dimitrov G. Infection with human papillomavirus in patients with cervical pre-neoplastic and neoplastic abnormalities. [Poster presentation] 12th Meeting of Balkan Clinical Laboratory Federation, Neptun, Romania, Abstract Book, p. 106, 2004.
22. Stojanovska V., Panov S., Dimitrov G., Roganovic-Zafirova D. Infection with human papillomavirus in patients with cervical intraepithelial II Congress of the gynecologists and obstetricians of Republic of Macedonia with international participation, Ohrid, Abstract Book, p. 70, 2003
23. Panov S., Gligorov D., Stojanovska V., Dimitrov G., Roganovic-Zafirova D. Point mutation in a HPV type 16 viral genome resulting in failure of genotypization. II Congress of the gynecologists and obstetricians of Republic of Macedonia with international participation, Ohrid, Abstract Book, p. 69, 2003.
24. Tanturovski D, Stojovski M, Petrovska M, Milanova E, Plasevski Z, Dokic E, Stojanovska V, Lazarova A. Genital HPV infections at women and marriage status.
25. Stojanovska V., Eleonora Jovcheva., Marga Stojmanovska., Sasho Panov. PCR-based detection of human papillomavirus in cervical swab samples. 24^th International medical student’s scientific Congress, Ochroid, Abstract Book, p.54, 2001.
26. Stojanovska V., Marga Stojmanovska., Sasho Panov. PCR-based microsatellite analysis of urinary bladder cancer. 24^th International medical student’s scientific Congress, Ochroid, Abstract Book, p.54, 2001.

 

Invited lectures:

October, 2017: Influence of embryo tranfer day on pregnancy outcomes.  13th World Congress of Perinatal Medicine, Belgrade.

May, 2015:       Oocytes Freezing. Macedonian Society of Human reproduction, Skopje

May, 2014:       Workshop title: In vitro fertilization – Contemporary techniques and cryopreservation of gametes and embryos. 37^th International Medical Scientific Congress, Ohrid.

December, 2013:  Freezing of gametes and embryos. Macedonian Society of Human reproduction, Skopje.

April, 2012:      High sophisticated methods in micromanipulations with gametes in the assisted reproduction and in vitro fertilization. New methods in gynecology and perinatology. Macedonian medical chamber. Skopje

September, 2007: Round table discussion for cervical cancer, public education and HPV vaccines. Perspectives in gynecological oncology & colposcopy teaching session. European Society of Gynecological Oncology (ESGO). Ohrid.

March, 2007:   Detection and typing of human papillomavirus with PCR-RFLP technique in cervical lesions at the Meeting of the Macedonian Society for Clinical biochemistry, Skopje.

March, 2005:     PCR-based detection of Human Papillomavirus in cervical swabs at the Annual Meeting of the Macedonian Society for Colposcopy and Cervical Pathology, Skopje.